Tag Archives: asprin

The delta variant is no big deal if you’re young or vaccinated.

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The toll of COVID-19 has been terrible: 660,000 dead by my count, based on excess deaths, graph below, or 620,000 according to the CDC based on hospital records. Death rates appear to have returned to pre-pandemic levels, more or less*, but folks are still getting very sick and going to the hospital, mostly for “the delta variant.”

Weekly US death rates since October 2015.

As the following chart shows, severe symptoms of COVID are now almost entirely in the old, and unvaccinated. The risk to the young and middle aged is low, but even there, vaccination helps. According to the CDC, 72.2% of the adult US population is vaccinated with at least one shot. The vaccination, doesn’t prevent you from getting the delta variant nor from spreading it; it just protects from the most serious consequences of the disease. It seems a previous infection has the same effect, though less so.

Vaccination helps prevent hospitalization – at all ages (Israeli data)

If you’re over 60 and unvaccinated, I recommend getting vaccinated with at least one shot; the inconvenience and side-effects are few, and the benefit is large. The second shot seemswothshile too, and for all I know a third will too. Sooner or later there is a diminishing return. The benefit of masks seems is smaller, as I judge things. I notice that the disease is spreading at about the same rate in masked and unmasked states, and that the death numbers are as high, or higher in heavily masked, blue states as in red. New York and NJ are the top COVID death states, with Michigan not far behind. Masks seem to help, just not very much.

For those who want further advice, I can suggest dilute iodine gargle. I did this when I got a sore throat, I also suggest got a pneumonia vaccination, and take and adult aspirin every other day for COVID and heart-attack prevention. I also take a vitamin D tablet every few days.

If you wish to check my analysis, go here to get the raw data: https://gis.cdc.gov/grasp/fluview/mortality.html. Then, to calculate the COVID effect, I subtracted the weekly death rates in 2020 and 2021 from the corresponding week rates in 2019, correcting the deaths by 1%/year for population growth and aging. *I find that there are about 500 excess deaths per week, and I assume those are among the unvaccinated. If you are vaccinated, I’d worry about something else besides COVID-delta: heart attack, cancer, suicide, or Afghanistan.

Robert Buxbaum August 18, 2021. I made a video of cute iodine reactions, including the classic “iodine clock”, where I use vitamin C as as the anti-oxidant (reducing agent).

Aspirin protection from heart attack and COVID-19 death.

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Most people know that aspirin can reduce blood clots and thus the risk heart attack, as shown famously in the 1989 “Physicians’ Health Study” where 22,000 male physicians were randomly assigned to either a regular aspirin (325 mg) every other day or an identical looking placebo. The results are shown in the table below, where “Myocardial Infarction” or “MI” is doctor-speak for heart attack.

TreatmentMyocardial InfarctionsNo InfarctionTotalfraction with MI
Aspirin13910,89811,037139/11,037 = 0.0126
Placebo23910,79511,034239/11,034 = 0.0217

Over the 5 years of the study, the physicians had 378 MI events, but mostly in the group that didn’t take aspirin: 1.28% of the doctors who took aspirin had a heart attack as opposed to 2.17% for those with the placebo. The ratio 1.28/2.17 = 0.58 is called the risk ratio. Apparently, aspirin in this dose reduces your MI risk to 58% of what it was otherwise — at least in white males of a certain age.

A blood clot showing red cells held together by fibrin fibers. Clots can cause heart attack, stroke, and breathing problems. photo: Steve Gschmeissner.

Further study showed aspirin benefits with women and other ethnicities, and benefits beyond hear attack, in any disease that induces disseminated intravascular coagulopathy. That’s doctor speak for excessive blood clots. Aspirin produced a reduction in stroke and in some cancers (Leukemia among them) and now it now seems likely that aspirin reduces the deadliness of COVID-19. Data from Wuhan showed that excessive blood clots were present in 71% of deaths vs. 0.4% of survivors. In the US, some 30% of those with serious COVID symptoms and death show excessive blood clots, particularly in the lungs. Aspirin and Vitamin D seem to help.

.The down-side of aspirin use is a reduction in wound healing and some intestinal bleeding. The intestinal bleeding is known as aspirin burn. Because of these side-effects it is common to give a lower dose today, just one baby aspirin per day, 81 mg. While this does does some good, It is not clear that it is ideal for all people. This recent study in the Lanset (2018) shows a strong relationship between body weight and aspirin response. Based on 117,279 patients, male and female, the Lanset study found that the low dose, baby aspirin provides MI benefits only in thin people, those who weigh less than about 60 kg (130 lb). If you weigh more than that, you need a higher dose, perhaps two baby aspirin per day, or a single adult aspirin every other day, the dose of the original doctors study.

In this study of COVID patients, published in July, those who had been taking aspirin fared far better than those who did not A followup study will examine the benefits of one baby aspirin (81 mg) with and without Vitamin D, read about it here. I should note that other pain medications do not have this blood-thinning effect, and would not be expected to have the same benefit.

While it seems likely that 2 baby aspirins might be better in fat people, or one full aspirin every other day, taking a lot more than this is deadly. During the Spanish flu some patients were given as much as 80 adult aspirins per day. It likely killed them. As Paracelsus noted, the difference between a cure and a poison is the dose.

Robert Buxbaum, November 27, 2020.