Virus and cancer treatment by your immune system

There are two standard treatments for a disease. One is through a chemical, pill or shot, often using a patented antibiotic or antiviral molecule, sometimes a radioactive chemical or anti-inflammatory. There have been quite a lot of success with these molecules especially against bacterial disease. E.g. penicillin, a molecule found in cheese, was quite effective against infection, syphilis, and even the viral disease, rabies. Still, in surprisingly many cases, a molecule that you’d expect should cure a disease does not. For this reason, recent research has looked into the other approach to a cure — use your own immune system.

In the most basic version of this approach, that of Paracelcius, is to give the patient nothing beyond sunshine, a clean dressing, and good food. In surprisingly many cases, this is enough to allow the patient’s own immune system will fight the disease successfully. Currently, this seems like our best option to fight COVID-19, the new Wuhan coronavirus.; antivirals seem to have no particular effect on COVID-19, as with rabies, but patients do get better on their own with time, and there is some indication that sunlight helps too, at least in fighting the disease spread, and perhaps in effecting a cure.

Your immune system is remarkably flexible. When it is up to the task, as in the video below white blood cells multiply enormously around the invader and attack. The white cells do not harm your body cells nor those of friendly bacteria, but rally to kill nearly any invader, even one the cells have never seen before. There is a minimum of side effects (fever, tiredness) but these go away after the invader is gone. The immune system then keeps the memory of the invader alive via “Memory T cells” so that it can attack more quickly if the same invader is seen again. This is what we call immunity, and it’s a type of protection that you generally don’t get from pills.

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Unfortunately, not every disease is fought well by the immune system alone. Measles, for example, or smallpox. For several of these diseases we’ve found we can activate the patient’s immune system with a vaccination, even after the patient contacts the disease. An injection of a weaker form of the disease seems to help kick-start the patients own immune system. Vaccination tends to have bad side-effects, but for many diseases, e.g. measles, the bad is outweighed by the good. Interestingly we’ve begun to use this approach on some cancers, too, and it seems to work. Immune therapy, it’s called.

Immune therapy is not generally the first line approach to cancer, but it might be the best for slow cancers, like prostate. Generally, in the fight against cancer, the preferred method is to removes as much of cancer cells as possible, and treat any missed cells using a mix of radiation and chemicals. This works but there are a lot of side-effects. Immune therapy is sort of similar, in a way. Instead of irradiating the bad cells inside the body, one takes the cancer cells outside of the body (or the virus molecules) and uses radiation and chemicals to knock off bits. These bits, a weakened form of the cancer or of the virus, are then cultured and re-injected into the body. Sometimes it works, sometimes not. For melanoma, skin cancer, immune therapy is found to works about 1/4 of the time. Why not more? It seems that sometimes the immune system gets “exhausted” fighting a foe that’s to much for it. And sometimes the activated immune system starts attacking the host body. This is an auto-immune response.

Dr. Robert E. Buxbaum, February 21, 2020

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  1. Pingback: COVID-19 in Sweden vs the US; different approaches, near identical outcomes. | REB Research Blog

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